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. 2020 Feb 13;10:2542. doi: 10.1038/s41598-020-59011-5

Figure 5.

Figure 5

Effect of D1 and D2 agonists on LID. D5 KO and WT littermates were treated with L-DOPA/Benserazide for 7 days. On day 8 SKF81297 (2 mg/kg, i.p.) was injected instead of L-DOPA and total AIMs, ALO and ROT scores assessed (A–C). After one day of L-DOPA treatment, on day 10 animals received quinpirole (0.5 mg/kg, i.p.) alone, and total AIMs, ALO and ROT scores were assessed (D–F). N = 7. On day 40 animals received SKF83959 (0.2 mg/kg, i.p.), and total AIMs, ALO and ROT scores were assessed (G–K). N = 6. Graphs show mean values +/− SEM. Statistical analysis was performed using Student’s t-test (A (p < 0.05), D (p = 0.98), G (p = 0.08), J (p < 0.05) and 2-way ANOVA (effect of genotype: (B): F(1,66) = 5.75, p < 0.05; (C): F(1,66) = 19.27, p < 0.0001; (E): F(1,66) = 0.002, p = 0.96; (F): F(1,66) = 0.0015, p = 0.97; (H): F(1,100) = 28.31, p < 0.0001; (I): F(1,100) = 20.73, p < 0.0001), (K) F(1,60) = 27.24, p < 0.0001). Sidak’s multiple comparisons post-test (***P < 0.001; **P < 0.01).