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. 2020 Feb 13;10:2581. doi: 10.1038/s41598-020-59394-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TEWL measurements of intact skin and superficial skin wounds. (a) With a suction blister device, a vacuum of 200 mm Hg was applied to the volar side of the lower arm to form blisters. TEWL measurements (right panel) were performed on non-dressed normal skin (N1 + N2), on normal skin covered by the occlusive wound dressing (N3 + N4) and on wounds. Wounds were measured clockwise starting from 3 o’clock (W1) up to 12 o’clock (W4). (b) The progression of mean TEWL of wound points. The wound points (W1–4) started with a high mean TEWL level compared to normal (N1 + 2) and adjacent skin points (N3 + 4). Wound levels increased from d0 to d2 and decreased very fast until d6 (dressing period) which indicates a fast healing process with both treatments. TEWL values were similar between treatments. n = 24, FAS cohort. Continuous line Alv, dotted line, control (Wilcoxon Signed Rank Test).