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. 2020 Feb 13;11:867. doi: 10.1038/s41467-020-14525-4

Fig. 5. FMN supplementation increases cellular tolerance to oxidative stress in Aβ42 strain.

Fig. 5

a Ratio of NADPH/(NADPH + NADP+) in the Aβ42 strain without or with FMN supplementation during EX and PD growth phases respectively (n = 4 ± SD; *P < 0.01). b Ratio of NADH/(NADH + NAD+) in the Aβ42 strain without or with FMN supplementation during EX and PD growth phases (n = 4 ± SD; *P < 0.01). c, d Aβ42 cells display an increased H2O2 tolerance when supplemented with FMN. Aβ42 cells without or with FMN supplement were grown to mid exponential phase (OD ≈  0.5–0.6) and treated with different concentrations of H2O2. Cell growth was monitored using a microplate reader (c) with lag phase time analyzed using the R package growthrates (d). The lag phase indicates the time from H2O2 treatment until maximum growth rate, determined by the exponential growth phase. Results shown are average values ± SD of biological duplicates. The asterisk (*) indicates significant difference (p < 0.05). Source data are provided as a Source Data file.