Table 3.
Description of Clostridioides difficile Infection Treatment Among All Treated Cases (n = 18,243) and a Subset with Severe Disease (n = 3250)
| All cases | Severe cases | |
|---|---|---|
| N (%) | N (%) | |
| Any metronidazole | N = 14,257 (78) | N = 2576 (79) |
| Dose | ||
| 500 mg | 13,088 (92) | 2473 (96) |
| Other | 535 (4) | 61 (2) |
| Unknown | 634 (4) | 42 (2) |
| Frequency | ||
| Three times a day | 11,778 (83) | 2130 (83) |
| Other | 1797 (13) | 403 (15) |
| Unknown | 682 (4) | 43 (2) |
| Route | ||
| Oral | 11,728 (82) | 1508 (58) |
| Intravenous | 2443 (17) | 1060 (41) |
| Unknown | 86 (< 1) | 8 (< 1) |
| Any vancomycin | N = 7683 (42) | N = 2042 (63) |
| Doses | ||
| 125 mg | 5077 (66) | 1305 (64) |
| 250 mg | 1795 (23) | 506 (25) |
| 500 mg | 444 (6) | 194 (9) |
| Other | 32 (< 1) | 9 (< 1) |
| Unknown | 335 (4) | 28 (1) |
| Frequency | ||
| Four times a day | 6874 (89) | 1895 (93) |
| Other | 427 (6) | 108 (5) |
| Unknown | 382 (5) | 39 (2) |
| Route | ||
| Oral | 7612 (99) | 2013 (99) |
| Rectal | 42 (< 1) | 24 (1) |
| Unknown | 29 (< 1) | 5 (< 1) |
| Any fidaxomicin | N = 313 (2) | N = 64 (2) |
| Doses | ||
| 200 mg | 284 (91) | 61 (95) |
| Other | 4 (1) | 0 |
| Unknown | 25 (8) | 3 (5) |
| Frequency | ||
| Two times a day | 281 (90) | 60 (94) |
| Three times a day | 2 (< 1) | 0 |
| Unknown | 30 (10) | 4 (6) |
| Route | ||
| Oral | 313 (100) | 64 (100) |
| Any treatment | N = 18,243 | N = 3250 |
| Monotherapy | ||
| Metronidazole | 10,173 (56) | 1162 (36) |
| Vancomycin | 3576 (20) | 626 (19) |
| Fidaxomicin | 117 (< 1) | 10 (< 1) |
| Combination therapy with metronidazole and vancomycin | ||
| Any | 4037 (22) | 1405 (43) |
| Sequential | 851 (5) | 176 (5) |
| Metronidazole first | 581 (3) | 113 (3) |
| Vancomycin first | 270 (1) | 63 (2) |
| Overlap | 3186 (17) | 1229 (38) |
| ≥ 2 days | 2925 (16) | 1141 (35) |
| Vancomycin taper | 866 (5) | 168 (5) |
| Probiotics | 3223 (18) | 701 (22) |
| Fecal microbiota transplant | 89 (< 1) | 10 (< 1) |
| Days from stool collection to therapy | ||
| ± 7 days | 15,811 (87) | 3019 (93) |
| ± 2 days | 13,117 (72) | 2798 (86) |
| Days of therapy, median (IQR) | 14 (11–15) | 14 (11–17) |
IQR interquartile range, mg milligrams