Compared with existing diabetic models, simulations based on the revised United Kingdom Prospective Diabetes Study (UKPDS) risk equations perform favorably well in predicting risk differences.

Diabetic models based on the revised UKPDS risk equations, such as the Cornerstone Diabetes Simulation presented herein, are thus potentially suitable for cost-effectiveness evaluations, which are mainly driven by risk differences.

This study highlights the importance of full transparency in documenting model inputs to ensure reproducibility of simulation results.