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. 2020 Feb 13;9(2):19. doi: 10.1038/s41389-020-0207-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a GLUT1 upregulation enhanced RBE cell xenograft tumor growth in nude mice, while GLUT1 knockdown reduced HuCCT1 growth. b The expression of MMP2 and cyclin D1 was evaluated using western blot assays with xenograft tissues. c IHC staining was used to detect Ki-67 expression in xenograft tissues. d Representative bioluminescence images, gross specimens, and hematoxylin and eosin (H&E) staining of the lung tumors are shown in the left panels. The number and incidence of nodules are displayed in the right panels. Bar = 100 μm. Data are means ± SD of three independent experiments. **P < 0.01; ***P < 0.001.