Figure 1.

Magnolol prevented cisplatin-induced body weight loss and systemic dysfunction. (A) Experimental schedule of cisplatin and magnolol injection. Briefly, muscle wasting was induced by cisplatin injection (2.5 mg/kg daily, total 10 times) and the protective effect of magnolol treatment (10 mg/kg, every 3 days) was observed. All mice were sacrificed on day 42. (B) Changes in body weight in a cisplatin-induced muscle wasting mouse model. (C) Relative body weight changes of control (con), magnolol (mag), cisplatin (cis), or both cisplatin and magnolol treated mice (cis+mag) were expressed as% vs. control (day 42). (D) Mean daily food uptake per mouse during whole period, and (E) representative images showing caecum, colon, and rectum (Scale bar: 1 cm). (F) Concentration of blood urea nitrogen (BUN) and (G) creatinine in blood serum after the termination of the experiment (day 42). All results are representative from three individual experiments (n = 6–7), and the graphs are expressed as the mean ± SEM. **P < 0.01; ***P < 0.001 vs. con, ^###P < 0.001 vs. mag, and ^$$$P < 0.001 vs. cis based on the one-way ANOVA Tukey's test. The letters for no significance were not shown.