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. 2020 Feb 7;11:77. doi: 10.3389/fimmu.2020.00077

Figure 2.

Figure 2

Magnolol protected cisplatin-induced muscle wasting. Protective effect of magnolol on muscle was assessed by measuring muscle mass, fiber diameter, and grip strength in the cisplatin-induced muscle wasting mouse model. Hind leg muscle tissues were harvested from control (con), magnolol (mag), cisplatin (cis), or cis+mag mice at the end of the experiment (day 42). (A–C) Muscle mass of (A) tibialis anterior (TA), (B) extensor digitalis longus (EDL), and (C) soleus (SOL). (D) Histological images of hematoxylin and eosin staining of TA muscle tissue (scale bar: 200 μm) and (E) measurements of fiber diameter in transverse sections. The grip strength of (F) forelimbs and (G) all-limbs measured using a digital force gauge (day 41). All data are representative of three individual experiments (n = 7), and presented as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 vs. con, #P < 0.05; ##P < 0.01; ###P < 0.001 vs. mag, and $P < 0.05; $$P < 0.01; $$$P < 0.001 vs. cis based on the one-way ANOVA Tukey's test. The letters for no significance were not shown.

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