Figure 4.

(A) Simulated macroscopic gating current evoked by a voltage pulse from −190 to −40 mV (protocol indicated above). The dashed rectangle represents the part of the gating current response expanded in the inset of (B). (B) Probability density functions for the x_S4 variable, assessed at various times from the beginning of the depolarization in the same simulation shown in (A). (C) Energy landscapes for x_s4 values around state 1 at the two indicated membrane voltages. To compare the two profiles, the energy values have been normalized to their value at x_s4 = −1.2 nm.