Table 2.

Agreement between proposed logical model and experimental data from the literature.

Stimulus/Perturbations	Response/Phenotype	Cell lines	Reference
miR-34a in NSCLC	Downregulated	A549, H460	5
In response to DNA damage, miR-34a in NSCLC	upregulated	A549, H460	5
miR-34a and c-Myc in NSCLC	Negative correlation	A549, H460	5
miR-34a KO in NSCLC	Apoptosis	A549, H460	5
miR-34a E1 in NSCLC	Inhibits Proliferation/induces Senescence and Apoptosis	A549, H460	5
c-Myc KO in NSCLC	Senescence and Apoptosis	A549, H460	5
E2F1 KO in NSCLC	Senescence and/or Apoptosis	A549, H460	?
Sirt-1 KO and E2F1 KO in NSCLC	Senescence and/or Apoptosis	A549, H460	?
miR-16 E1 and RB KO in NSCLC	Apoptosis	A549, H460	4
miR-16 E1 and RB E1 in NSCLC	Senescence and/or Apoptosis	A549, H460	4
miR-16 E1 in NSCLC	Senescence and/or Apoptosis	A549, H460	4
miR-34a and miR-16 in NSCLC	Downregulated	A549, H460	1
In response to DNA damage, miR-34a and miR-16 in NSCLC	Upregulated	A549, H460	1
miR-34a E1 and RB E1	Senescence	A549, H460	1
miR-34a E1 and miR-16 E1	Senescence and/or Apoptosis	A549, H460	1
miR-34a KO and miR-16 KO	Apoptosis	A549, H460	1
miR-16 in CTCL	Downregulated	MyLa, MJ	2
In response to DNA damage, miR-16 in CTCL	Upregulated	MyLa, MJ	2
miR-16 and BMI1 in CTCL	Negative correlation	MyLa, MJ	2
miR-16 KO in CTCL	Apoptosis	MyLa, MJ	2
miR-16 E1 in CTCL	Senescence and/or Apoptosis	MyLa, MJ	2
BMI1 KO in CTCL	Senescence and/or Apoptosis	MyLa, MJ	2
RB KO in CTCL cell	Directly affects miR-16 expression	MyLa, MJ	?
RB E1 in CTCL cell	Increased miR-16 expression	MyLa, MJ	?
Sirt-1 E1 in CTCL cell	Apoptosis	MyLa, MJ	?

E1 represents GoF and KO represents LoF of the corresponding gene. Question marks indicate predictions of the model since we did not find experimental data to support it.