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. 2020 Feb 7;8:35. doi: 10.3389/fbioe.2020.00035

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Copyright © 2020 Xing, Yang, Liu, Cui, Meng, Zhao, Zhao, Li, Liu, Zhang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The distribution of DE genes. (A) The expression atlas of significantly up-regulated genes in different preimplantation development stages. The gene expression level was normalized by Seurat (see Materials and Methods). (B–D) The intersection between DE genes (B: zygote/oocyte, C: 2-cell/oocyte, D: 4-cell/oocyte) and maternal/zygotic genes. The maternal and zygotic gene sets were derived from Fan et al. (2015). (E) The distribution of DE genes overlapped with maternal and zygotic genes. Zygotic genes marked with red color denotes the up-regulated genes overlapped with zygotic genes from Fan et al. (2015). Maternal genes marked with black color denotes the down-regulated genes overlapped with maternal genes from Fan et al. (2015).