Table 4.
Characteristics of epithelial ovarian cancer patient by BRCA1/2 tumor and germline (hereditary) status
| Workflow characteristics | No BRCA1/2 mutation n = 254 | Germline mutation n = 25 | Somatic mutation *n = 19 |
P
†
|
||
|---|---|---|---|---|---|---|
| Germline vs somatic | Germline vs normal | Somatic vs normal | ||||
| Age at OC diagnosis, median (IQR), y | 66 (57–73) | 57 (52–65) | 59 (54–72) | 1.0 | .009 | .90 |
| Initial OC histology, No. (%) | .27 | 1.0 | 1.0 | |||
| Serous, low grade | 16 (6.3) | – | 1 (5.3) | |||
| Serous, high grade | 155 (61.0) | 21 (84.0) | 12 (63.2) | |||
| Serous, unknown grade | 17 (6.7) | – | 1 (5.3) | |||
| Mucinous | 16 (6.3) | – | 1 (5.3) | |||
| Endometrioid | 12 (4.7) | – | 3 (15.8) | |||
| Clear cell | 18 (7.1) | 1 (4.0) | – | |||
| Carcinosarcoma | 9 (3.5) | 1 (4.0) | – | |||
| Adenocarcinoma NOS | 2 (.8) | – | – | |||
| Undifferentiated | 6 (2.4) | 2 (8.0) | 1 (5.3) | |||
| HGS OC, No. (%) | ||||||
| Yes | 155 (61.0) | 21 (84.0) | 12 (63.2) | .49 | .09 | 1.0 |
| No | 99 (39.0) | 4 (16.0) | 7 (36.8) | |||
*
This includes only patients for whom the presence of a BRCA1/2 germline mutation was evaluated; hence, seven patients for whom results of germline diagnostics are unavailable were excluded. HGS = high-grade serous; IQR = interquartile range; NOS = not otherwise specified; OC = epithelial ovarian cancer; – = a count of zero.
†
P values were calculated with Mann-Whitney U tests or Fisher exact tests and adjusted with a Bonferroni correction for the three group comparisons.