Table 2.
Abnormal screens, biopsies, and cancers detected by screen type, age group, and risk criteria*
| Performance measures | MRI plus mammography† |
Mammography† |
MRI† |
|||||
|---|---|---|---|---|---|---|---|---|
| No. | Rate (95% CI) | No. | Rate (95% CI) | P ‡ | No. | Rate (95% CI) | P ‡ | |
| Abnormal screens, %§ | 4472 | 22.3 (21.7 to 22.9) | 2003 | 10.0 (9.6 to 10.4) | <.001 | 3121 | 15.6 (15.0 to 16.1) | <.001 |
| Initial | 2594 | 29.5 (28.6 to 30.5) | 1115 | 12.7 (12.0 to 13.4) | <.001 | 1922 | 21.9 (21.0 to 22.8) | <.001 |
| Rescreen | 1878 | 16.7 (16.0 to 17.4) | 888 | 7.9 (7.4 to 8.4) | <.001 | 1199 | 10.6 (10.1 to 11.2) | <.001 |
| Biopsies, %§ | 1429 | 7.1 (6.8 to 7.5) | 426 | 2.1 (1.9 to 2.3) | <.001 | 1315 | 6.6 (6.2 to 6.9) | <.001 |
| Initial | 845 | 9.6 (9.0 to 10.3) | 265 | 3.0 (2.7 to 3.4) | <.001 | 786 | 9.0 (8.4 to 9.6) | <.001 |
| Rescreen | 584 | 5.2 (4.8 to 5.6) | 161 | 1.4 (1.2 to 1.7) | <.001 | 529 | 4.7 (4.3 to 5.1) | <.001 |
| Cancers detected per 1000 screens‡,‖ | 280 | 14.0 (12.4 to 15.7) | 109 | 5.4 (4.5 to 6.6) | <.001 | 263 | 13.1 (11.6 to 14.8) | .24 |
| Screen type | ||||||||
| Initial | 150 | 17.1 (14.6 to 20.0) | 60 | 6.8 (5.3 to 8.8) | <.001 | 144 | 16.4 (13.9 to 19.3) | .11 |
| Rescreen | 130 | 11.5 (9.7 to 13.7) | 49 | 4.3 (3.3 to 5.7) | <.001 | 119 | 10.6 (8.8 to 12.6) | .25 |
| Age at index screen, y | ||||||||
| 30–39 | 60 | 10.7 (8.3 to 13.9) | 26 | 4.7 (3.2 to 6.8) | <.001 | 57 | 10.2 (7.8 to 13.3) | .62 |
| 40–49 | 96 | 11.9 (9.8 to 14.5) | 35 | 4.3 (3.1 to 6.1) | <.001 | 90 | 11.2 (9.1 to 13.7) | .44 |
| 50–69 | 124 | 19.3 (16.2 to 23.0) | 48 | 7.5 (5.6 to 9.9) | <.001 | 116 | 18.1 (15.1 to 21.7) | .41 |
| Risk criteria¶ | ||||||||
| Known mutation carrier | 129 | 26.8 (22.6 to 31.8) | 52 | 10.8 (8.2 to 14.2) | <.001 | 121 | 25.1 (21.1 to 30.0) | .42 |
| Family history and ≥25% risk# | 131 | 9.4 (7.9 to 11.2) | 48 | 3.5 (2.6 to 4.6) | <.001 | 122 | 8.8 (7.3 to 10.5) | .36 |
| Untested, first-degree relative | 5 | 10.7 (4.5 to 25.6) | 3 | 6.4 (2.1 to 19.9) | .24 | 5 | 10.7 (4.5 to 25.6) | .99 |
| Chest radiation therapy | 15 | 17.1 (10.3 to 28.1) | 6 | 6.8 (3.1 to 15.1) | .01 | 15 | 17.1 (10.3 to 28.1) | .99 |
n = 20 053 screens: initial n = 8782; rescreen n = 11 271. CI = confidence interval; MRI = magnetic resonance imaging.
Mammography refers to an abnormal mammogram result irrespective of MRI result; MRI refers to an abnormal MRI result irrespective of mammogram result; MRI plus mammography refers to an abnormal MRI and/or abnormal mammogram result.
Compared with MRI plus mammography.
Adjusted for repeated measures within women.
n = 280 cancers among n = 278 women.
If a woman met more than one risk criterion, the following hierarchy was selected to classify her: known carrier; family history ≥25% lifetime risk; untested, first-degree relative; chest radiation therapy.
Based on International Breast Cancer Intervention Study and/or Breast and Ovarian Analysis of Disease Incidence of Carrier Estimation Algorithm.