Table 4.
Adjusted specificity (%) and 95% CI stratified by age group and risk criteria (n = 16 915 screens)
| Characteristics | True-negative + false-positive tests | MRI plus mammography* |
Mammography* |
MRI* |
|||
|---|---|---|---|---|---|---|---|
| True- negative tests | Specificity (95% CI) | True- negative tests | Specificity (95% CI) | True- negative tests | Specificity (95% CI) | ||
| Overall† | 16 915 | 13 168 | 81.0 (78.7 to 83.1) | 15 217 | 91.8 (90.6 to 92.8)‡ | 14 354 | 87.3 (85.6 to 88.9)‡ |
| Age at index screen, y | |||||||
| 30–39§ | 4868 | 3527 | 74.1 (72.7 to 75.4) | 4262 | 88.6 (87.6 to 89.5)‡ | 3921 | 81.9 (80.8 to 83.1)‡ |
| 40–49§ | 6770 | 5199 | 77.0 (76.0 to 78.1) | 6091 | 90.2 (89.5 to 90.9)‡ | 5686 | 84.3 (83.4 to 85.2)‡ |
| 50–69§ | 5277 | 4442 | 84.2 (83.1 to 85.2) | 4864 | 92.3 (91.5 to 93.0)‡ | 4747 | 90.0 (89.2 to 90.9)‡ |
| Known carrier, ‖ | 4209 | 3525 | 84.2 (83.0 to 85.4) | 3874 | 92.5 (91.6 to 93.3)‡ | 3775 | 90.2 (89.2 to 91.1)‡ |
| 30–39§ | 844 | 649 | 78.0 (74.7 to 80.9) | 742 | 88.7 (86.3 to 90.7)‡ | 720 | 86.2 (83.5 to 88.5)‡ |
| 40–49§ | 1146 | 916 | 80.0 (77.4 to 82.3) | 1043 | 91.2 (89.3 to 92.7)‡ | 995 | 87.0 (84.8 to 88.9)‡ |
| 50–69§ | 2219 | 1960 | 88.0 (86.5 to 89.4) | 2089 | 94.0 (92.9 to 95.0)‡ | 2060 | 92.7 (91.5 to 93.7)‡ |
| Family history & ≥25% risk, ‖, ¶ | 11 545 | 8 720 | 76.3 (75.5 to 77.1) | 10 279 | 89.6 (89.0 to 90.2)‡ | 9591 | 83.8 (83.1 to 84.5)‡ |
| 30–39§ | 3603 | 2575 | 73.3 (71.7 to 74.9) | 3143 | 88.4 (87.3 to 89.4)‡ | 2874 | 81.3 (80.0 to 82.7)‡ |
| 40–49§ | 5191 | 3933 | 76.1 (74.9 to 77.3) | 4652 | 89.9 (89.0 to 90.7)‡ | 4312 | 83.4 (82.4 to 84.4)‡ |
| 50–69§ | 2751 | 2212 | 80.4 (78.8 to 81.9) | 2484 | 90.4 (89.2 to 91.5)‡ | 2405 | 87.5 (86.2 to 88.7)‡ |
| Untested, first-degree relative§, ‖, # | 402 | 322 | 81.5 (77.0 to 85.3) | 370 | 93.0 (89.9 to 95.2)‡ | 344 | 86.9 (83.2 to 89.9)‡ |
| Chest radiation therapy§, ‖, # | 759 | 601 | 79.4 (75.8 to 82.5) | 694 | 91.7 (89.3 to 93.6)‡ | 644 | 85.1 (82.2 to 87.7)‡ |
Mammography refers to an abnormal mammogram result irrespective of MRI result; MRI refers to an abnormal MRI result irrespective of mammogram result; MRI plus mammography refers to an abnormal MRI and/or abnormal mammogram result. CI = confidence interval; MRI = magnetic resonance imaging.
Adjusted for age at index screen, screen type (initial, rescreen), prior breast cancer, and risk criteria.
Compared with MRI plus mammography (P < .001).
Adjusted for age at index screen and screen type (initial, rescreen).
If a woman met more than one risk criterion, the following hierarchy was selected to classify her: known carrier; family history ≥25% lifetime risk; untested, first-degree relative; chest radiation therapy.
Based on International Breast Cancer Intervention Study and/or Breast and Ovarian Analysis of Disease Incidence of Carrier Estimation Algorithm.
Excluded from stratified analysis by age group because of small numbers.