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. 2020 Feb 7;11:39. doi: 10.3389/fphar.2020.00039

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Copyright © 2020 Tan, Yu, Yang, Tao, Xiang, Xiao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF10 reduced cell death in ischemic kidneys. (A) Representative sections from kidney tissues 1 day after reperfusion for the detection of nuclear DNA fragmentation performed by terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) staining. Panels are representative of five rats in each group. Scale bars represent 50 μm. (B) Quantitative analysis of the proportion of TUNEL-positive renal tubular epithelial cells in kidney tissues of each group.1.19% in Sham group, 17.3% in I/R group, 1.5% in I/R–FGF10 group. FGF10 significantly reduced the apoptosis of renal tubular epithelial cells after reperfusion. Representative data of five individual samples for each group. ^**P < 0.001.