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. 2020 Feb 7;11:39. doi: 10.3389/fphar.2020.00039

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Copyright © 2020 Tan, Yu, Yang, Tao, Xiang, Xiao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulation effect of FGF10 on ER stress and ERK1/2 signaling pathway. (A) The expression levels of GRP-78, CHOP, XBP-1, ATF-4, ATF-6, PDI, ERK1/2, and phospho-ERK1/2 in kidney tissues of Sham group, I/R group and I/R-FGF10 group were determined by immunoblot analysis. FGF10 significantly increased the phosphorylation of ERK1/2. (B–I) The histograms show the normalized optical density analysis. Results are representative of five rats in each group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ns represents no significant difference.