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. 2020 Feb 7;11:39. doi: 10.3389/fphar.2020.00039

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Copyright © 2020 Tan, Yu, Yang, Tao, Xiang, Xiao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF10 reduced the expression of proapoptotic proteins via activating ERK1/2 signaling pathway. (A) For protein analysis of in vitro samples, total proteins of NRK-52E were extracted using cell lysis buffer. NRK-52E was treated with different culture media and then the expression of cleaved Caspase-3, cleaved Caspase-9, Bax, Bcl-2, ERK1/2, and phosphor-ERK1/2 was detected by western blotting. (B–E) Histogram figures show the normalized optical density analysis. Results are representative of five rats in each group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.