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. 2020 Feb 7;11:39. doi: 10.3389/fphar.2020.00039

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Copyright © 2020 Tan, Yu, Yang, Tao, Xiang, Xiao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF10 attenuates ER stress in NRK-52E cells. (A, B) Immunofluorescent staining for CHOP and GRP78 in NRK-52E. FGF10 significantly decreased the expression of CHOP and GRP78 in NRK-52E induced by TBHP, whereas U0126 largely eliminated the effect of FGF10. Panels are representative of five rats in each group. Scale bar represents 50 μm. (C) The expression of CHOP and GRP78 was detected by Western blotting. (D, E) Bar chart for quantification analysis for the expression of CHOP and GRP78. Results are representative of five rats in each group. GAPDH was used as a protein loading control. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.