Fig. 4.

HBMSC-Exos accelerates xenograft tumor growth and pulmonary metastasis in vivo. (A) MG63 cells treated with hBMSC-Exos markedly promoted tumor growth while silencing ATG5 in MG63 cells significantly inhibited tumor growth. Tumor volume and weight were calculated; n = 6 mice/group. (B) Representative images of pulmonary metastases in the three different groups were obtained by the IVIS Imaging System; n = 6 mice/group. (C) Representative H&E-stained lung sections from mice in the three different groups. (D and E) IHC staining of proliferation marker (Ki67) in tumor and lung sections in the three different groups.