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. 2020 Jan 17;16(5):882–892. doi: 10.7150/ijbs.40960

Figure 6.

Figure 6

IC261 modulates aerobic glycolysis in colon cancer cells through p53-dependent mechanism. (A, B) The expression of p53, TIGAR and G6PD of RKO and HCT116 in NC and p53 siRNA group was detected by using Western blotting. (C) Glucose uptake was measured in RKO and HCT116 treated by IC261 with NC or p53 siRNA. (D) Lactate production was measured in RKO and HCT116 treated by IC261 with NC or p53 siRNA. (E) Glucose uptake was measured in RKO and HCT116 treated by IC261 with or without p53 inhibitor Pifithrin-α. (F) Lactate production was measured in RKO and HCT116 treated by IC261 with or without p53 inhibitor Pifithrin-α (*p<0.05 vs control group, &p<0.05 vs IC261 group).