Table 2.

Downregulated circRNAs in lung cancer (LC)

CircRNA	Expression Change	Function	Clinical relevance	Possible Mechanism	Reference
circRNA-ITCH	down	proliferation(-)	Unknown	Wnt/β-catenin	43
hsa_circ_0043256	down	proliferation(-) apoptosis(+)	Unknown	Wnt/β-catenin	44
circ0006916	down	proliferation(-)	Unknown	miRNA sponge	45
circRNA-FOXO3	down	proliferation(-) migration(-) invasion(-) apoptosis(+)	Unknown	miRNA sponge	46
hsa_circ_0046264	down	proliferation(-) apoptosis(+)	Unknown	Wnt/beta-catenin	47
circ_0001946	down	proliferation(-) migration(-) invasion(-) apoptosis(+)	Unknown	Nucleotide Excision Repair Signaling	48
circPTPRA	down	proliferation(-) migration(-) invasion(-) EMT(-)	metastasis OS	circPTPRA/miR-96-5p/RASSF8/E-cadherin	49
hsa_circ_0033155	down	proliferation(-) migration(-) PTEN(+)	LNM	Not mentioned	54
circ_0086414	down	Not mentioned	Unknown	Not mentioned	55