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. 2020 Jan 20;10(5):2422–2435. doi: 10.7150/thno.37106

Figure 3.

Figure 3

CD226 deletion prevents infarct expansion and ameliorates cardiac remodeling after MI. A. Gross observation of infarcted hearts (top) and the ratio of heart weight to tibia length (HW/TL) (bottom). B. Representative images of Masson trichrome staining of heart cross sections of WT and CD226 KO mice at 1 week and 5 weeks after MI. Scale bar =1 mm. C-D. Infarct scar circumference (C) was expressed as a percentage of LV including the septum, and wall thickness of infarct scar (D) at papillary muscle level was measured 1week and 5 weeks after MI. n=6 in each group at each time point, * P<0.05 vs. corresponding WT. E. CD226 KO mice exhibited more preserved myocardium (1 week post-MI) and increased collagen deposition (5 weeks post-MI) in the infarct zone, and decreased interstitial fibrosis in the border zone. Scale bar =50 μm. F-H. Ratio of myocyte to fibrosis 1 week after MI (F) and collagen density 5 weeks after MI (G) in the infarct zone, and collagen volume fraction in the border zone (H) were quantitatively estimated in 5 randomly chosen high-power fields (×200) in each section. Results obtained from the same heart were averaged and counted as n=1. n = 6 in each group at each time point, * P<0.05 and ** P<0.01 vs. corresponding WT. Data are expressed as mean±SEM.