(A) Schematic illustrating anti-metastasis by small molecule inhibitors and anti-growth by photodynamic-AIEgens in an orthotopic ovarian cancer model. (B) The images of EGFP and TPD@TB/KBU2046 NPs of primary tumor in vivo. EGFP (Ex=500 nm, Em=540 nm); TPD@TB/KBU2046 (Ex=540 nm, Em=680 nm). (C) Images of recurrent and metastatic tumors after treatment. EGFP (Ex=500 nm, Em=540 nm) (D) The amount of cancerous ascites after treatment. (E) Relative fluorescence intensity of recurrent and metastatic tumors after treatment. (F) Weight changes in mice during treatment. Data were presented as the mean ± SD (n =3) and analyzed by two-sided Student's t-test. n.s. not significant, * P <0.05, ** P <0.01 *** P <0.001.