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. 2020 Jan 16;10(5):2358–2373. doi: 10.7150/thno.40397

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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High IKKε expression correlates with metastasis and poor prognosis in human colorectal cancer. (A) Immunohistochemical staining for IKKε expression in human colorectal cancer tissues and paired adjacent tissues. Scale bar, 200 μm. (B) IKKε protein levels in 161 paired human colorectal cancer tissues and the adjacent normal tissues, measured by immunohistochemical analysis (***P <0.001). (C) Immunohistochemical staining for IKKε expression in human colorectal cancer tissue. Scale bar, 200 μm (top) and 100 μm (bottom). (D) IKKε protein levels in cancer tissues according to lymph node metastasis. (N classification) (**P<0.01). (E) Kaplan-Meier analysis of overall survival in a set of 191 colorectal cancer patients according to IKKε expression (log-rank test, p=0.001).