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. 2020 Jan 12;10(5):2243–2259. doi: 10.7150/thno.35861

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Bioinformatics analysis of possible mechanism of ZNF471 functions in ESCC cells. (A) Ectopic expression of ZNF471 in KYSE150 and KYSE410 cells. (B) Entire distribution of differentially expressed genes in vector- and ZNF471-stably transfected KYSE410 cell is shown by a volcano plot. (C) Hierarchical cluster analysis of selected differentially expressed genes in R software is shown as a heat map (gene functional annotation: PCDH family genes, CLDN1 and CNTN1 involved in cell adhesion, MAPK10/JNK3 and PYCARD involved in cell apoptosis, TUSC3 and SAMD9L involved in tumor suppression, and IFNL3 involved in immunity regulation). (D-G) Validation of differentially expressed genes in KYSE150 and KYSE410 cells ectopically expressing ZNF471 by qRT-PCR. Student's test was used. Data are presented as the mean ± SD. *p<0.05, **p<0.01, ***p<0.001.