Table 3.
Degree of tissue damage scored in H&E sections of the skin-fold chamber collected 48 h after PDT with 2 anti-EGFR nanobody-photosensitizer conjugates. Mean of 3 to 5 animals per group.
| Control | 7D12-PS | 7D12-9G8-PS | No tumor | |||
|---|---|---|---|---|---|---|
| 1 h | 24 h | 1 h | 24 h | All NB-PS 1 or 24h |
||
| Damage to epithelium | - | +++ | + | +++ | - | - |
| Damage to muscle cells around tumor |
- | +++ | - | +++/++ | - | - |
| Damage to muscle cells away from tumor |
- | ++ | - | ++/+ | - | - |
| Damage to blood vessels around tumor |
- | +++ | - | +++ | - | - |
| Damage to blood vessels away from tumor |
- | ++ | - | ++/+ | - | - |
| Neutrophils | Few | Some | Some | Few | Few | - |