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Cascade conversion of tyrosine to curcuminoids using a co-culture system. One E. coli strain converts tyrosine to ferulic acid and the other one converts ferulic acid and coumaric acid to different curcuminoids. TAL, tyrosine ammonia lyase; C3H, 4-coumarate 3-hydroxylase; COMT, caffeic acid O-methyltransferase; 4CL, 4-coumarate-CoA ligase; DCS, diketide-CoA synthase; CURS1, curcumin synthase.
