. 2020 Feb 14;9(2):e1106. doi: 10.1002/cti2.1106

Table 2.

Studies of Tfr cells in patients with non‐AIDs and vaccine responses

Disease	Authors	Molecular phenotype of Tfr cells	Main findings
HIV	Colineau et al. 87	CD3⁺CD4⁺CD45RA^–CCR7⁻CXCR5⁺Foxp3⁺	GC Tfr↑
	Miles et al. 85	CD4⁺Foxp3⁺CD20⁺IgD⁺	GC Tfr↑, proliferation↑, apoptosis↓, regulatory function↑
	Miller et al. 84	CXCR5⁺CD25⁺ CD127⁻(Tfr) and CXCR5⁺PD1⁺CD25⁺CD127⁻(GC Tfr)	Tfr↑, GC Tfr↑, Tfh↑, GC Tfh↑, and Tfr is highly permissive to R5‐tropic HIV‐1
CHB	Wu et al. 82	CD4⁺CXCR5⁺Foxp3⁺	cTfr↑, cTfr/cTfh↑ and are positively correlated with FIB‐4 and APRI
HCV	Cobb et al. 83	CD4⁺CXCR5⁺PD‐1⁺CD25⁺Foxp3⁺	Tfr↑, expression of CTLA‐4 on Tfr↑, suppression capacity↑
CHB CHC	Wang et al. 88	CD4⁺CXCR5⁺Foxp3⁺	cTfr↑, cTfh↓, cTfr is positively correlated with serum HBV DNA, HBsAg and ALT in CHB patients, and also HCV RNA and ALT in CHC patients
Schistosomiasis	Chen et al. 86	CD3⁺CD4⁺CXCR5⁺Foxp3⁺	cTfr↑, CD45RA⁻ cTfr↑
Breast cancer	Faghih Z et al. 91	CD4⁺Bcl6⁺CXCR5^int/hi	Tfr↑, Tfh↑
NSCLC	Guo et al. 90	CD4⁺CXCR5⁺ ICOS⁺Foxp3⁺	cTfr↑, cTfh↑
Ovarian carcinoma	Li et al. 89	CD4⁺CD25⁺CD127⁻CXCR5⁺/CD4⁺CD25⁺CD127⁻ CXCR5⁺Foxp3⁺	cTfr↑, the expression of TGFB1 and IL10↑, suppression capacity↑
LTFA	Bruyne et al. 93	CD3⁺CD4⁺CD45RO⁺CXCR5⁺CD25⁺ Foxp3⁺	cTfr↓
AR	Yao et al. 92	CD3⁺CD4⁺CD45RA^lowCXCR5^high/CD3⁺CD4⁺CD45RA^lowCXCR5⁺CD25^highCD127^lowFoxp3⁺	Tfr↓ and is negatively correlated with antigen‐specific IgE production and disease activity, the suppression capacity↓
CGR	Chen et al. 94	CD4⁺CXCR5⁺ICOS⁺Foxp3⁺CD127⁻	Tfr↓, IL‐21–Tfh↑ in AMR patients
ARDS	Li et al. 95	CD4⁺Foxp3⁺CXCR5⁺	cTfr↑, expression of CTLA‐4 and IL‐10 on Tfr↓, the suppression capacity↓
Influenza vaccination	Dhaeze et al. 15	CD4⁺CD25⁺CD127⁻CXCR5⁺ PD‐1⁺	cTfr↑
Influenza vaccination	Fonseca et al. 14	CXCR5⁺Foxp3⁺CD4⁺/CXCR5⁺CD25⁺CD127⁻CD4⁺	cTfr↑

AIDs, autoimmune diseases; ALT, serum alanine transaminase; AMR, antibody‐mediated rejection; APRI, aspartate transaminase‐to‐platelet ratio index; AR, allergic rhinitis; ARDS, acute respiratory distress syndrome; CGR, chronic graft rejection; CHB, chronic hepatitis B; CHC, chronic hepatitis C; FIB‐4, fibrosis index based on four factors; GC, germinal centre; HCV, hepatitis C virus; HIV, human immunodeficiency virus; LTFA, post‐transplant food allergy; NSCLC, non–small‐cell lung cancer; Tfr, follicular regulatory T.