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. 2019 Dec 29;9(1):90. doi: 10.3390/jcm9010090

Figure 1.

Figure 1

Body weight, tumor number and size in colitis-induced carcinogenesis model mice. (A) Chemical structure of fucoxanthin (Fx). (B) Experimental protocol for AOM/DSS induced colorectal carcinogenesis. Fx-oil was administrated to groups 1 and 3 at 30 mg Fx/kg bw every 1–3 days during the final 3 weeks before sacrifice (red arrows). The control groups with or without AOM/DSS treatment were given the equivalent volume (μl) of control-oil (Fx-free) (black arrows). (C) Body weight changes during the period of Fx administration. (D) Tumor number. Means ± SE (Fx, n = 13; control, n = 15). (E) Estimated tumor size. Means ± SE (Fx, n = 38; control, n = 101). The parentheses are 95% confidence intervals. Significant differences in tumor number (D) and estimated tumor size (E) were performed by Wilcoxon rank sum test (vs. group 2). * p < 0.05. AOM: Azoxymethane DSS: dextran sodium sulfate.