Table 6.
Comparison of incident and prevalent patients with pulmonary arterial hypertension.
| Incident Cases | Prevalent Cases | p | |
|---|---|---|---|
| Number | 96 | 874 | |
| Age [years] | 62.7±16.9 | 52.7±17.7 | <0.0001 |
| Female sex (n,%) | 69(71.8) | 608(69.6) | 0.6 |
| BMI [kg/m2] | 27.4±5.6 | 25.7±5.4 | 0.0003 |
| Diagnosis (n,%): | |||
| IPAH/HPAH | 48 (50.0) | 396 (45.3) | 0.03 |
| CTD-APAH | 20(20.8) | 112(12.8) | 0.03 |
| CHD-APAH | 19(19.8) | 337(38.8) | 0.0003 |
| WHO-FC | |||
| I | 1(1) | 48(5.5) | <0.0001 |
| II | 15(15.6) | 440(50.3) | |
| III | 63(65.6) | 366(42.9) | |
| IV | 17(17.7) | 20(2.3) | |
| 6MWD [m] | 289 ± 136 | 384 ± 140 | <0.0001 |
| NTproBNP [ng/L] | 3133.7 ± 5367.9 | 1670.1 ± 7653.8 | 0.07 |
| RAA [cm2] | 25.3 ± 8.1 | 23.8 ± 9.3 | 0.16 |
| Right heart catheterization: | |||
| CI [l/min/m2] | 2.4 ± 0.95 | 2.8 ± 0.86 | 0.22 |
| mPAP [mmHg] | 45.5 ± 15.1 | 51.2 ± 19.3 | 0.006 |
| PVR [WU] | 8.9 ± 4.5 | 9.7 ± 7.3 | 0.35 |
| RAP [mmHg] | 7.4 ± 4.7 | 6.7 ± 4.4 | 0.61 |
| Concomitant diseases (n,%): | |||
| Hypertension | 55(57.3) | 314(35.9) | <0.0001 |
| Diabetes mellitus | 28(29.1) | 126(14.4) | 0.002 |
| Smoking | 6(6.3) | 35(4.0) | 0.3 |
| Previous smoking | 33 (34) | 159 (18) | 0.0002 |
| Coronary artery disease | 21(21.8) | 92(10.5) | 0.001 |
| Myocardial infarction | 9(9.4) | 33(3.8) | 0.01 |
| Chronic kidney disease | 19(19.8) | 128(14.6) | 0.18 |
| Atrial fibrillation | 24(25.0) | 142(16.2) | 0.08 |
| Atrial flutter | 4(4.2) | 48(5.5) | 0.88 |
BMI—body mass index, IPAH—idiopathic pulmonary arterial hypertension, CHD—congenital heart disease, CI—cardiac index, CTD—connective tissue disease, mPAP—mean pulmonary artery pressure, 6 MWD—six min walking distance, NT-proBNP—N-terminal pro-B-type Natriuretic Peptide, PVR—pulmonary vascular resistance, RAA—right atrial area, RAP—right atrial pressure, WHO-FC—World Health Organization Functional Class.