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. 2019 Dec 28;12(1):35. doi: 10.3390/v12010035

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Self-assembly of the I5350 nanoparticle. (A) Polypeptide I53–50A.1NT1; shown in red is the N-terminus projecting outward, where antigens can be displayed. I53–50A.1NT1 naturally trimerizes forming a 3-fold symmetry axis. (B) The I53–50B.4PT1 protein (orange) assembles into a pentamer. (C) I53–50A.1NT1 trimer and I53–50B.4PT1 pentamer self-assemble as a nanoparticle. (D) Assembled nanoparticle formed by 20 trimers and 12 pentamers, the N-termini of I53–50A.1NT1 is shown in red, and the black triangle represents the 3-fold symmetry axis of each pair of trimers. The figure was prepared using PyMOL software (The PyMOL Molecular Graphics System, Version 4.5 Schrödinger, LLC).