Figure 3.

Intracellular mechanisms involved in inflammatory responses of IL-17A in the kidney. IL-17A can binds to its receptors and activates several intracellular mechanisms. The activation of NF-κB pathway and the upregulation of proinflammatory factors, such as MCP-1 can contribute to renal inflammation, as proposed under diabetic conditions. IL-17A can also activate other mechanisms, such as protein kinases and redox processes, but their role in renal damage have not been fully demonstrated.