Table 5.
The trend in changes of selected cytokines and chemokines determined after bacteriochlorin-based PDT. The analysis was performed using Luminex multiplexing assay in the serum of individual mice before and after PDT (N = 6–7).
| PS | F2BOH | F2BMet | Cl2BHep | ||||
|---|---|---|---|---|---|---|---|
| Cytokine | V-PDT | V-PDT | E-PDT | C-PDT | V-PDT | E-PDT | C-PDT |
| IL-6 | ⬆⬆ | ⬆ | ⬆ | ⬆ | ⬆ | ⬆⬆ | ⬆ |
| IL-10 | ⇧ | − | ⇧ | ⇧ | ⇧ | − | ⬆ |
| IL-13 | ⬆ | ⇩ | ⇩ | − | ⬆ | ⬆ | ⇧ |
| IL-15 | ⇧ | ⇧ | − | ⇧ | ⬆ | ⬆ | ⬆ |
| KC | ⬆ | ⬆ | ⬆ | ⬆ | ⬆ | ⬆⬆ | ⬆ |
| MIP-2 | ⬆ | − | ⬆ | ⬆ | − | ⬆ | ⇧ |
| LIX | ⬆ | ⇩ | ⇩ | − | − | ⇩ | ⇩ |
| LIF | ⇧ | ⇧ | ⇧ | − | − | − | ⬇ |
| MCP-1 | ⬆ | − | ⬆ | ⬆ | ⬆ | ⇧ | ⬆ |
| MIP-1α | − | ⬆ | ⬆ | − | − | ⇧ | ⇩ |
| MIP-1β | ⇩ | − | ⬆ | − | − | ⇧ | ⇩ |
| IP-10 | ⬆ | − | ⬆ | − | ⬇ | − | ⬆ |
| MIG | ⬆ | ⬆ | ⬇ | − | ⬆ | − | − |
| GM-CSF | ⇧ | − | ⇩ | − | − | − | − |
| VEGF | ⬇ | ⬇ | − | − | ⬇ | − | ⇩ |
| TNFα | ⬆ | ⬆ | ⇧ | − | − | − | ⬆ |
⬆, ⬇ indicated significantly (min two-times) increased or decreased the level of each biomarker, ⇧ and ⇩ are symbols for the non-significant (higher or lower) tendency in the concentration of biomarker. The tendencies were estimated in comparison to values obtained in the serum of the same individual animals before PDT.