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Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivates from latency in response to ER stress. In response to ER stress, XBP1 mRNA is spliced and the XBP1s protein accumulates and translocates to the nucleus, where it transactivates the RTA gene encoding the lytic switch protein. RTA binds and transactivates viral early gene promoters throughout the genome and commits the virus to the lytic gene expression program and virion production.
