Table 1.

Characterization of TrkB isoforms.

Name	Characterization	Relevance of PD
TrkB-L1	lacked the first two LRMs of three leucine-rich motifs (LRMs) in the ECD	ND	[63]
TrkB-L0	lacked the all of three leucine-rich motifs (LRMs) in the ECD	ND	[63]
TrkB.T1	467-477 AA: PASVISNDDDS → FVLFHKIPLDG 478-822 AA: Missing	Involved	[64]
TrkB.T2	Contain only 23 amino acids of the ICD.	Involved	[64]
TrkB-T-Shc	529-537 AA: FVQHIKRHN → WPRGSPKTA 538-822 AA: Missing.	ND	[54,65]
TrkB-T-TK	710-735 AA: GGHTMLPIRWMPPESIMYRKFTTESD → SSCADQRPQGPLSLRDPCCICLLRLS 736-822 AA: Missing.	ND	[54,65]
TrkB-N	lack of N-terminal signal sequence	ND	[65]
TrkB-N-T-TK	710-735 AA: GGHTMLPIRWMPPESIMYRKFTTESD → SSCADQRPQGPLSLRDPCCICLLRLS 736-822 AA: Missing.	ND	[54,65]
TrkB-N-Shc	529-537 AA: FVQHIKRHN → WPRGSPKTA 538-822 AA: Missing.	ND	[54,65]
TrkB-N-T1	1-156 AA: Missing. 467-477 AA: PASVISNDDDS → FVLFHKIPLDG 478-822 AA: Missing.	ND	[54,65]
TrkB.Kin	Additional six-AA insertion between the Ig2 and the TM	ND	[66]

TM, transmembrane region; ICD, intracellular domain; ECD, extracellular domain; TKD, tyrosine kinase domain; LRRNT, leucine-rich repeat N-terminal domain; LRR1, leucine-rich repeat region 1; LRR2, leucine-rich repeat region 1; ND, not determined.