Table 2.
Mortality risk by HbA1c categories among participants not treated with agents causing hypoglycaemia.
| HbA1c Target Categories | Unadjusted | Adjusted | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||||||
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| C2 (ref) | 1.00 | - | <0.001 | 1.00 | - | <0.001 | 1.00 | - | <0.001 | 1.00 | - | <0.001 |
| C1 | 0.92 | 0.78–1.10 | 0.36 | 1.01 | 0.85–1.20 | 0.94 | 1.03 | 0.87–1.23 | 0.70 | 1.03 | 0.87–1.22 | 0.74 |
| C3 | 1.36 | 1.12–1.66 | 0.01 | 1.34 | 1.10–1.63 | 0.01 | 1.28 | 1.05–1.55 | 0.02 | 1.26 | 1.04–1.54 | 0.02 |
| C4 | 1.67 | 1.35–2.07 | <0.001 | 1.72 | 1.39–2.13 | <0.001 | 1.59 | 1.28–1.97 | <0.001 | 1.50 | 1.21–1.86 | <0.001 |
Cox proportional hazards regression according to HbA1c categories plus use of agents causing hypoglycaemia, unadjusted and adjusted for age and gender (model 1), plus CVD risk factors (model 2), plus complications/comorbidities (model 3). HRs (95% CI) for mortality are shown for each HbA1c category. HbA1c = haemoglobin A1c; HR = hazard ratio; CI = confidence interval; C1 = HbA1c < 6.5%; C2 = HbA1c 6.5–7.49%; C3 = HbA1c 7.5–8.49%; C4 = HbA1c ≥ 8.5%.