Table 3.
Performance of multi-target stool DNA test (mt-sDNA).
| Number of Events/Total | Sensitivity | Specificity | PPV | NPV | LR+ | LR− | |
|---|---|---|---|---|---|---|---|
| (%, 95% CI) | (%, 95% CI) | (%, 95% CI) | (%, 95% CI) | (95% CI) | (95% CI) | ||
| Mt-sDNA | |||||||
| Any polyp | 56/82 | 50 (36–67) | 81 (61–93) | 85 (71–93) | 43 (35–51) | 2.60 (1.13–5.96) | 0.62 (0.45–0.85) |
| AA | 13/82 | 54 (25–81) | 62 (50–74) | 21 (13–33) | 88 (79–93) | 1.43 (0.79–2.57) | 0.74 (0.40–1.37) |
| ASL | 10/82 | 90 (56–98) | 67 (55–67) | 27 (20–36) | 98 (88–100) | 2.70 (1.83–3.97) | 0.15 (0.02–0.97) |
| AN | 22/82 | 68 (45–86) | 70 (57–81) | 46 (34–57) | 86 (76–92) | 2.27 (1.41–3.67) | 0.45 (0.24–0.86) |
Any polyp = non-advanced and advanced adenoma and serrated polyp; AA = advanced adenoma; ASL = advanced serrated lesion; AN = advanced neoplasia; CI = confidence interval; PPV = positive predictive value; NPV = negative predictive value; LR+ = likelihood ratio positive; LR− = likelihood ratio negative.