Table 4.
Performance of fecal immunochemical test at cut-off of ≥10 µg Hb/g feces (FIT10) and multi-target stool DNA test (mt-sDNA) combined.
| Number of Events/ Total |
Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | PPV (%, 95% CI) | NPV (%, 95% CI) | LR+ (95% CI) | LR− (95% CI) | |
|---|---|---|---|---|---|---|---|
| Combined stool test | |||||||
| Any polyp | 24/65 | 50 (35–65) | 66 (43–85) | 76 (62–86) | 39 (29–49) | 1.50 (0.77–2.94) | 0.75 (0.49–1.14) |
| AA | 12/65 | 50 (21–79) | 57 (42–70) | 21 (12–33) | 83 (73–90) | 1.15 (0.61–2.19) | 0.88 (0.48–1.63) |
| ASL | 7/65 | 100 (59–100) | 62 (48–75) | 24 (19–31) | 100 * | 2.64 (1.90–3.66) | 0 |
| AN | 18/65 | 67 (41–87) | 64 (49–77) | 41 (30–54) | 83 (72–91) | 1.84 (1.12–3.04) | 0.52 (0.26–1.04) |
Any polyp = non-advanced and advanced adenoma and serrated polyp; AA = advanced adenoma; ASL = advanced serrated lesion; AN = advanced neoplasia; CI = confidence interval; PPV = positive predictive value; NPV = negative predictive value; * = calculation not possible (due to no false negative results); LR+ = likelihood ratio positive; LR- = likelihood ratio negative; FIT10 (≥10 µg Hb/g feces).