Table 1.
Demographical and clinical characteristics comparing clear cell adenocarcinoma to other carcinomas of the urinary bladder.
| Clear Cell Adenocarcinoma (N = 91) | Non-Clear Cell Adenocarcinoma (N = 205,106) | |||||
|---|---|---|---|---|---|---|
| Count | % | Count | % | p-Value | ||
| Age | 0–60 | 27 | 29.7 | 37,649 | 18.4 | 0.005 |
| 61+ | 64 | 70.3 | 167,457 | 81.6 | ||
| Sex | Female | 54 | 59.3 | 49,241 | 24.0 | <0.001 |
| Male | 37 | 40.7 | 155,865 | 76.0 | ||
| Race | White | 77 | 84.6 | 182,492 | 89.0 | 0.001 |
| Black | 13 | 14.3 | 11,519 | 5.6 | ||
| Other | 1 | 1.1 | 8588 | 4.2 | ||
| Unknown | 0 | 0.0 | 2507 | 1.2 | ||
| Tumor primary site | Trigone of bladder | 9 | 9.9 | 12,765 | 6.2 | <0.001 |
| Dome of bladder | 4 | 4.4 | 7213 | 3.5 | ||
| Lateral wall of bladder | 6 | 6.6 | 41,041 | 20.0 | ||
| Anterior wall of bladder | 5 | 5.5 | 4334 | 2.1 | ||
| Posterior wall of bladder | 7 | 7.7 | 18,819 | 9.2 | ||
| Bladder neck | 10 | 11.0 | 6354 | 3.1 | ||
| Ureteric orifice | 4 | 4.4 | 7820 | 3.8 | ||
| Urachus | 1 | 1.1 | 310 | 0.2 | ||
| Overlapping lesion of bladder | 13 | 14.3 | 21,112 | 10.3 | ||
| Bladder, NOS | 32 | 35.2 | 85,338 | 41.6 | ||
| Grade | Grade I | 0 | 0.0 | 23,684 | 11.5 | <0.001 |
| Grade II | 5 | 5.5 | 48,123 | 23.5 | ||
| Grade III | 22 | 24.2 | 35,849 | 17.5 | ||
| Grade IV | 25 | 27.5 | 59,477 | 29.0 | ||
| Unknown | 39 | 42.9 | 37,973 | 18.5 | ||
| AJCC 6th stage | Stage 0 | 2 | 2.2 | 105,545 | 51.5 | <0.001 |
| Stage 1 | 22 | 24.2 | 46,332 | 22.6 | ||
| Stage 2 | 28 | 30.8 | 23,463 | 11.4 | ||
| Stage 3 | 9 | 9.9 | 8157 | 4.0 | ||
| Stage 4 | 17 | 18.7 | 14,012 | 6.8 | ||
| Unknown | 13 | 14.3 | 7597 | 3.7 | ||
| T stage | Tis/Ta | 2 | 2.2 | 105,545 | 51.5 | <0.001 |
| T0 | 0 | 0.0 | 91 | 0.0 | ||
| T1 | 26 | 28.6 | 49,221 | 24.0 | ||
| T2 | 35 | 38.5 | 28,776 | 14.0 | ||
| T3 | 7 | 7.7 | 8046 | 3.9 | ||
| T4 | 11 | 12.1 | 7713 | 3.8 | ||
| Unknown | 10 | 11.0 | 5714 | 2.8 | ||
| N stage | N0 | 70 | 76.9 | 189,973 | 92.6 | <0.001 |
| N1 | 2 | 2.2 | 3994 | 1.9 | ||
| N2 | 6 | 6.6 | 3806 | 1.9 | ||
| N3 | 1 | 1.1 | 166 | 0.1 | ||
| Unknown | 12 | 13.2 | 7167 | 3.5 | ||
| M stage | M0 | 75 | 82.4 | 193,071 | 94.1 | <0.001 |
| M1 | 11 | 12.1 | 7565 | 3.7 | ||
| Unknown | 5 | 5.5 | 4470 | 2.2 | ||
| Bone metastasis a | No | 42 | 97.7 | 102,083 | 97.0 | 0.697 |
| Yes | 0 | 0.0 | 1432 | 1.4 | ||
| Unknown | 1 | 2.3 | 1698 | 1.6 | ||
| Brain metastasis a | No | 41 | 95.3 | 103,393 | 98.3 | <0.001 |
| Yes | 1 | 2.3 | 122 | 0.1 | ||
| Unknown | 1 | 2.3 | 1698 | 1.6 | ||
| Liver metastasisa | No | 40 | 93.0 | 102,600 | 97.5 | 0.028 |
| Yes | 2 | 4.7 | 926 | 0.9 | ||
| Unknown | 1 | 2.3 | 1687 | 1.6 | ||
| Lung metastasis a | No | 41 | 95.3 | 102,153 | 97.1 | 0.771 |
| Yes | 1 | 2.3 | 1327 | 1.3 | ||
| Unknown | 1 | 2.3 | 1733 | 1.6 | ||
| Type of surgical procedure | No surgery | 8 | 8.8 | 15,265 | 7.4 | <0.001 |
| Local procedure/partial cystectomy | 60 | 65.9 | 170,325 | 83.0 | ||
| Complete cystectomy | 22 | 24.2 | 18,327 | 8.9 | ||
| Surgery NOS | 0 | 0.0 | 504 | 0.2 | ||
| Unknown if surgery performed | 1 | 1.1 | 685 | 0.3 | ||
| Type of radiation b | None | 67 | 85.9 | 160,440 | 94.6 | <0.001 |
| Beam radiation | 9 | 11.5 | 7485 | 4.4 | ||
| Other radiation | 1 | 1.3 | 219 | 0.1 | ||
| Unknown if radiation received | 1 | 1.3 | 1389 | 0.8 | ||
Bolded are statistically significant p-values when comparing between clear cell adenocarcinoma to other carcinomas of the urinary bladder. NA—not applicable. a Variable only available for cases diagnosed after 2010. b Variable only available for cases diagnosed before 2013.