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. 2020 Jan 3;9(1):134. doi: 10.3390/jcm9010134

Figure 1.

Figure 1

Schematic diagram demonstrating the possible effects of decitabine in primary erythroid cells from healthy donors. Decitabine promotes apoptosis through activation of stress responses, and increases transcriptional activity by downregulation of transcriptional repressors. Proteins in red circles are some of the differentially expressed proteins identified in ratio 1 (i.e., healthy treated/healthy un-treated cultures). The red arrows indicate whether the proteins are up- or down-regulated by decitabine.