Table 4.
Outcome comparison of clinical PICS patients with lymphocytopenia ** versus clinical PICS patients without lymphocytopenia.
| Characteristics | Normal Lymphocyte Count (n = 9) | Lymphocytopenia (n = 9) | p-Value |
|---|---|---|---|
| Hospital days | 58 (40–128) | 92 (71–110) | 0.401 |
| ICU days | 19 (16–25) | 27 (23–36) | 0.001 |
| Tracheostomy | 4 (44.4%) | 8 (88.9%) | 0.131 |
| Mechanical ventilation days | 21 (16–27) | 35 (31–60) | 0.001 |
| Continuous veno-venous hemofiltration | 0 (0%) | 3 (33.3%) | 0.206 |
| Infectious complications during hospitalization | 9 (100%) | 9 (100%) | 0.999 |
| Per patient | 3 (3–3) | 3 (3–4) | 0.090 |
| Multi-drug resistant organisms | 0.217 | ||
| MRSA | 1 (11.1%) | 0 (0%) | |
| ESBL | 2 (22.2%) | 0 (0%) | |
| MDR-GNB | 1 (11.1%) | 3 (33.3%) | |
| Multi-drug resistant Pseudomonas | 0 (0%) | 2 (22.2%) | |
| Multi-drug resistant Acinobacter | 0 (0%) | 1 (11.1%) | |
| Sepsis * | 7 (77.8%) | 6 (66.7%) | 0.999 |
| Infectious readmissions | 5 (55.6%) | 7 (77.8%) | 0.620 |
| Per patient | 1 (0–1) | 2 (1–5) | 0.050 |
| Total infectious complications during or after hospitalization per patient | 3 (3–4) | 6 (4–8) | 0.020 |
| Surgical procedures during hospitalization | 9 (100%) | 9 (100%) | 0.999 |
| Per patient | 4 (2–10) | 9 (6–15) | 0.156 |
| Surgical procedures after discharge | 4 (44.4%) | 7 (77.8%) | 0.335 |
| Per patient | 0 (0–3) | 5 (1–15) | 0.037 |
| Total surgical procedures during or after hospitalization per patient | 7 (2–12) | 17 (8–24) | 0.051 |
| Discharge | 0.091 | ||
| Other hospital | 1 (11.1%) | 1 (11.1%) | |
| Nursing home | 1 (11.1%) | 1 (11.1%) | |
| Rehabilitation facility | 2 (22.2%) | 6 (66.7%) | |
| Home (+/− additional care) | 5 (55.6%) | 1 (11.1%) | |
| Totally mortality | 0 (0%) | 2 (22.2%) | 0.471 |
| In hospital | 0 (0%) | 1 (11.1%) | 0.999 |
| <3 years | 0 (0%) | 1 (11.1%) | 0.999 |
All data are shown as n (%) or median (IQR). ICU = Intensive care unit. OSM = Osteosynthesis material. UTI = Urinary tract infection. MRSA = Methicillin-resistant Staphylococcus aureus. ESBL = Extended Spectrum Beta-Lactamase. MDR-GNB = Multidrug-resistant Gram-negative bacilli. Mortality <3 years does not included mortality during hospitalization. Variables are compared between patient meeting the PICS markers criteria and those not meeting the PICS markers criteria with a Fisher’s exact test, a Mann–Whitney U test or a Student T-test * Sepsis = defined as an increase in SOFA score >2 in response to infection. ** Lymphocytopenia = defined as lymphocyte count below 0.8 × 109/L for 2 or more consecutive days.