Table 1.

Metabolites found to be significantly different in PAH cohort vs. heart or DM cohorts.

Metabolites	Fold Heart	p-Value	Fold DM	p-Value
oxalic acid	45.23	4.35 × 10−5	82.10	2.24 × 10−8
aminomalonate	3.00	6.52 × 10−5	2.75	6.12 × 10−3
pseudo uridine	2.62	2.31 × 10−4	3.07	8.86 × 10−5
gluconic acid	2.35	6.25 × 10−8	1.55	1.33 × 10−2
isothreonic acid	2.05	1.31 × 10−5	2.09	9.85 × 10−4
4-hydroxyphenylacetic acid	2.02	1.57 × 10−2	2.24	2.77 × 10−3
erythritol	2.01	3.16 × 10−3	2.83	1.56 × 10−3
uric acid	1.99	2.28 × 10−3	1.79	4.85 × 10−2
UDP-glucuronic acid	1.98	4.45 × 10−3	4.49	2.77 × 10−4
fumaric acid	1.95	3.81 × 10−5	1.37	1.16 × 10−2
focuse	1.86	1.68 × 10−3	1.68	3.40 × 10−3
aconitic acid	1.86	5.21 × 10−5	3.14	1.68 × 10−9
2-deoxytetronic acid	1.78	1.36 × 10−2	2.17	7.04 × 10−5
pantothenic acid	1.75	7.33 × 10−3	1.69	8.60 × 10−4
indole-3-acetate	1.59	9.92 × 10−3	2.06	1.16 × 10−3
myo-inositol	1.50	2.52 × 10−2	1.65	2.32 × 10−2
2-hydroxyvaleric acid	1.48	3.27 × 10−2	2.12	5.16 × 10−3
citric acid	1.48	2.97 × 10−2	2.01	1.81 × 10−4
ribonic acid	1.48	6.03 × 10−4	2.61	5.75 × 10−4
glycine	1.44	5.18 × 10−2	1.41	4.17 × 10−2
glutamic acid	1.40	4.91 × 10−2	0.68	3.59 × 10−2
creatinine	1.38	1.55 × 10−2	1.58	8.82 × 10−4
glucuronic acid	1.37	8.21 × 10−4	2.66	1.77 × 10−4
phosphate	1.28	4.56 × 10−2	4.54	2.09 × 10−11
indole-3-lactate	1.26	3.59 × 10−2	1.85	4.37 × 10−6
urea	1.21	2.91 × 10−2	1.47	2.49 × 10−2
2-hydroxyglutaric acid	0.78	2.88 × 10−2	1.55	2.80 × 10−4
tryptophan	0.76	4.66 × 10−3	0.51	7.55 × 10−8
tyrosine	0.74	7.99 × 10−3	0.67	3.43 × 10−5
glutamine	0.73	4.99 × 10−3	0.71	2.97 × 10−2
lysine	0.72	4.38 × 10−4	0.56	2.20 × 10−6
histidine	0.51	1.34 × 10−5	0.45	8.65 × 10−7