Table 2.
The hemodynamic parameters of the two groups of patients.
| T0 | H3 | H6 | H24 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Oliguric/Anuric Group | Normal Urinary Output Group | p Value | Oliguric/Anuric Group | Normal Urinary Output Group | p Value | Oliguric/Anuric Group | Normal Urinary Output Group | p Value | Oliguric/Anuric Group | Normal Urinary Output Group | p Value | |
| SOFA Mean ± SD points | 11.3 ± 2.9 | 8.8 ± 3.2 | 0.02 | not calculated at the 3rd h | 10.1 ± 3.1 | 8.4 ± 3.6 | 0.11 | 10.0 ± 2.5 | 7.2 ± 3.6 | 0.02 | ||
| SOFAcv Mean ± SD points | 3.4 ± 1.2 | 2.5 ± 1.3 | 0.03 | 3.0 ± 1.6 | 2.8 ± 1.5 | 0.22 | 3.0 ± 1.6 | 2.3 ± 1.5 | 0.03 | |||
| SOFAr Mean ± SD points | 3.1 ± 1.4 | 1.9 ± 1.6 | 0.03 | 2.8 ± 1.5 | 1.3 ± 1.5 | 0.01 | 2.7 ± 1.3 | 1.1 ± 1.3 | 0.00 | |||
| SOFAp Mean ± SD points | 2.4 ± 1.2 | 1.8 ± 1.2 | 0.02 | 2.2 ± 1.2 | 1.0 ± 1.0 | 0.18 | 2.1 ± 0.9 | 1.6 ± 1.0 | 0.12 | |||
| APACHE II Mean ± SD points | 23.3 ± 8.5 | 20.8 ± 8.4 | 0.17 | not calculated at 6th h | not calculated at 24th h | |||||||
| SBD Mean ± SD mm Hg | 121.1 ± 23.9 | 117.5 ± 19.9 | 0.53 | 124.2 ± 18.5 | 123.0 ± 17.9 | 0.80 | 126.1 ± 17.3 | 127.9 ± 18.5 | 0.70 | 130.5 ± 17.9 | 130.1 ± 20.0 | 0.93 |
| DBP Mean ± SD mm Hg | 57.7 ± 14.5 | 55.6 ± 10.0 | 0.67 | 58.0 ± 11.9 | 55.0 ± 11.9 | 0.34 | 60.5 ± 12.0 | 56.5 ± 11.7 | 0.21 | 60.4 ± 12.3 | 59.5 ± 13.3 | 0.80 |
| MAP Mean ± SD mm Hg | 74.3 ± 16.4 | 75.8 ± 12.8 | 0.68 | 75.4 ± 10.9 | 75.2 ± 11.9 | 0.94 | 78.7 ± 14.1 | 78.6 ± 11.7 | 0.97 | 78.5 ± 15.2 | 82.4 ± 12.7 | 0.29 |
| Heart rate Mean ± SD beats/min | 108.5 ± 19.2 | 101.5±17.9 | 0.15 | 101.7 ± 18.7 | 96.5 ± 18.3 | 0.26 | 100.1 ± 21.0 | 98.1 ± 19.5 | 0.90 | 101.1 ± 14.9 | 95.5±17.4 | 0.25 |
| CVP Mean ± SD mm Hg | 8.5 ± 4.2 | 6.8 ± 4.7 | 0.08 | 10.7 ± 3.9 | 7.6 ± 4.9 | 0.006 | 11.2 ± 3.7 | 8.2 ± 4.9 | 0.01 | 7.7 ± 3.9 | 8.3 ± 4.6 | 0.96 |
| CI Mean ± SD l/min | not monitored at time 0 | 3.2 ± 0.8 | 3.5 ± 0.9 | 0.20 | 3.1 ± 0.8 | 3.7 ± 0.9 | 0.03 | 3.2 ± 0.6 | 3.5 ± 0.7 | 0.23 | ||
| SVI Mean ± SD mL/m2/beat | 31.5 ± 9.4 | 37.0 ± 9.6 | 0.03 | 34.1 ± 12.2 | 38.0 ± 10.0 | 0.27 | 33.1 ± 8.6 | 38.0 ± 10.4 | 0.07 | |||
| GEDI Mean ± SD mL/kg | 565.8 ± 133.6 | 661.8 ± 158.4 | 0.037 | 530.9 ± 199.3 | 651.9 ± 203.0 | 0.07 | 605.1 ± 120.6 | 707.4 ± 153.6 | 0.009 | |||
| ITBI Mean ± SD mL/m2 | 754.5 ± 215.6 | 764.6 ± 153.0 | 0.15 | 761.9 ± 247.0 | 858.3 ± 262.2 | 0.20 | 776.4 ± 247.8 | 931.4 ± 229.8 | 0.009 | |||
| ELWI Mean ± SD mL/kg | 7.9 ± 2.0 | 8.7 ± 3.3 | 0.88 | 8.88 ± 3.03 | 8.9 ± 4.0 | 0.49 | 8.8 ± 2.2 | 8.5 ± 3.0 | 0.45 | |||
| GEF Mean ± SD | 23.6 ± 8.7 | 22.3 ± 5.8 | 0.91 | 23.6 ± 9.8 | 22.7 ± 6.2 | 0.96 | 22.7 ± 7.0 | 21.1 ± 6.2 | 0.64 | |||
| SVRI Mean ± SD dynes * sec/cm5/m2 | 1584.4 ± 477.4 | 1638.9 ± 476.4 | 0.97 | 1554.3 ± 472.3 | 1623.7 ± 512.1 | 0.85 | 1678.0 ± 588.0 | 1765.6 ± 536.0 | 0.69 | |||
| Norepinephrine Mean ± SD mcg/kg/min | 0.18 ± 0.19 | 0.06 ± 0.07 | 0.001 | 0.14 ± 0.14 | 0.08 ± 0.08 | 0.08 | 0.17 ± 0.16 | 0.10 ± 0.12 | 0.11 | 0.24 ± 0.30 | 0.12 ± 0.19 | 0.02 |
| VDI Mean ± SD | 0.26 ± 0.27 | 0.08 ± 0.1 | 0.001 | 0.19 ± 0.19 | 0.12 ± 0.13 | 0.14 | 0.24 ± 0.25 | 0.16 ± 0.21 | 0.19 | 0.35 ± 0.43 | 0.12 ± 0.19 | 0.01 |
| Creatinine Mean ± SD) µmol/L | 291.7 ± 226.3 | 192.76 ± 179.5 | 0.06 | not monitored at these time frames | 249.3 ± 191.8 | 184.8 ± 165.3 | 0.14 | |||||
| Urea Mean ± SD mmol/L | 20.32 ± 13.7 | 14.6 ± 11.28 | 0.09 | 19.0 ± 10.7 | 15.3 ± 11.6 | 0.11 | ||||||
| Mean urinary output Mean ± SD mL/kg/hour | 0.12 ± 0.12 | 1.26 ± 0.75 | <0.001 | |||||||||
| Lactate (septic shock patients) mean ± SD mmol/L | 4.1 ± 2.0 | 3.5 ± 2.3 | 0.12 | 3.6 ± 2.0 | 3.6 ± 3.4 | 0.08 | 3.5 ± 1.5 | 3.7 ± 3.4 | 0.18 | 2.2 ± 1.2 | 2.5 ± 2.7 | 0.18 |
| Lactate clearance ≥ 10% (septic shock patients) % | not monitored between time of presentation and time zero | 53.8 | 44.4 | 0.60 | 53.8 | 44.4 | 0.60 | 84.6 | 94.4 | 0.36 | ||
| Capilary refill time > 3 sec % | 31.60 | 16.30 | 0.16 | 26.30 | 10.10 | 0.09 | 21.10 | 6.2% | 0.06 | 5.30 | 4.10 | 0.08 |
T0: time zero, time of study inclusion; H3, H6, H24: 3rd, 6th, and 24th h transpulmonary thermodilution calibrations performed in Ev1000. SOFAcv: cardiovascular SOFA; SOFAr: renal SOFA; SOFAp: pulmonary SOFA; SBD: systolic blood pressure; DBP: dyastolic blood pressure; MAP: mean arterial blood pressure; CVP: central venous pressure; CI: cardiac index; SVI: stroke volume index; GEDI: global end-dyastolic index; ITBI: intrathoracic blood index; ELWI: extravscular lung water index; GEF: global ejection fraction; SVRI: systemic vascular resistance index; VDI: vasopressor dependency index.