Table 2.

Cox proportional hazards and logistic regression models for progression-free survival (PFS) and overall survival (OS).

Items	PFS (Univariate Analysis)		OS (Univariate Analysis)
	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Age > 75 Years	0.81 (0.34–1.91)	0.63	1.45 (0.55–3.80)	0.45
Male Gender	1.47 (0.66–3.26)	0.35	2.39 (0.80–7.17)	0.12
Smoker	1.508 (0.63–3.59)	0.35	2.50 (0.73–8.58)	0.14
ECOG-PS ≥ 2	2.21 (1.00–4.83)	0.048	4.23 (1.65–10.89)	0.0028
Squamous Histology	1.08 (0.47–2.48)	0.86	0.67 (0.24–1.83)	0.43
EGFR Mutations Positive	0.83 (0.28–2.43)	0.73	1.17 (0.34–4.02)	0.80
BMI > 20	0.47 (0.22–0.99)	0.047	0.42 (0.17–1.02)	0.056
BMI > 25	0.54 (0.19–1.59)	0.27	0.92 (0.26–3.25)	0.90
Corticosteroids Administration	1.3 (0.49–3.52)	0.58	0.66 (0.19–2.27)	0.51
Alb > 3.5 g/dL	0.53 (0.25–1.11)	0.092	0.37 (0.15–0.90)	0.028
CRP > 1.0 mg/dL	1.44 (0.68–3.04)	0.34	2.92 (1.10–7.76)	0.032
LDH > 245 U/L	1.41 (0.67–2.99)	0.37	2.16 (0.89–5.24)	0.090
NLR > 5.0	2.22 (1.02–4.84)	0.045	1.98 (0.79–4.92)	0.14
LMR > 1.7	0.44 (0.21–0.93)	0.032	0.51 (0.21–1.23)	0.14
PLR > 262	2.23 (0.99–5.03)	0.054	2.80 (1.02–7.67)	0.045
Liver Metastasis	1.79 (0.61–5.28)	0.29	1.95 (0.55–6.886)	0.30
Brain Metastasis	1.17 (0.47–2.91)	0.73	0.58 (0.17–2.00)	0.39
PD-L1 TPS 1–49%	0.32 (0.096–1.05)	0.059	0.55 (0.16–1.89)	0.34
PD-L1 TPS > 50%	0.35 (0.12–1.05)	0.061	0.42 (0.12–1.49)	0.18
Lines between First and Second ICIs > 2	1.26 (0.55–2.87)	0.58	1.54 (0.59–4.04)	0.38
PFS of First ICI >120 d	1.06 (0.50–2.23)	0.89	1.30 (0.55–3.08)	0.54
Duration from the End of the First ICI to the Second ICI >157 d	0.97 (0.47–2.02)	0.94	0.77 (0.32–1.84)	0.55
Partial Response with First ICIs	0.58 (0.26–1.33)	0.20	0.99 (0.40–2.48)	0.98