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Alternative HIV-1 RRE conformers promote different rates of virus replication. (A) Conformer construction (see text). (B) Chemical acylation (SHAPE) confirms a 5 SL conformation of mutant M1 and a 4 SL conformation of mutant M3. (C) Heteroduplex tracking analysis. In both M1/wt and M1/M3 mutant co-infections, the stabilized 5 SL M1 conformer displays a replicative growth advantage. The full experimental background is provided in Reference [52].
