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Restricting RRE conformational flexibility with multivalent branched peptides. (A) Cartoon depicting the branched peptide strategy, i.e., binding in a multivalent fashion to enhance affinity and selectivity toward the RNA target. (B) Structure of branched peptide 4A5. (C) Inhibition of Rev-RRE function in vivo using HEK 293T cells transiently transfected with a Rev-expressing plasmid and a CMV promoter-driven GagPol-RRE plasmid. Modified from Dai et al. [77].
