Figure 1.

Comorbidities in rheumatoid arthritis (RA). RA is a chronic inflammatory disease characterized by alterations in lipid profile, a high prevalence of metabolic syndrome, sarcopenic obesity, insulin resistance, altered insulin signaling and disorders in muscle lipid metabolism. All of these perturbations contribute to CV disease and thus, to an increased morbi-mortality in RA patients. CRP: C—reactive protein; CV: Cardiovascular; DG: Diglycerides; HDL-c: High-density lipoprotein-cholesterol; IL-6: interleukine-6; IL-1β: interleukine-1β; LDL-c: Low-density lipoprotein-cholesterol; ox-LDL-c: oxidized low-density lipoprotein-cholesterol; TC: Total cholesterol; TG: Triglycerides; TNF-α: Tumorous Nuclear Factor α.