Table 5.
Univariate analyses of factors linked to walking speed (WS) decline (<1.0 m/s).
| Variables | WS ≥ 1.0 m/s (n = 305) |
WS < 1.0 m/s (n = 51) |
p-Value |
|---|---|---|---|
| Age (years) | 64 (29, 90) | 73 (25, 94) | <0.0001 |
| Gender, male/female | 139/166 | 26/25 | 0.5446 |
| HBV/HCV/HBV and HCV/NBNC | 56/151/8/90 | 5/30/1/15 | 0.4421 |
| Body mass index (kg/m2) | 22.9 (14.8, 41.4) | 22.4 (14.6, 30.6) | 0.1246 |
| Presence of LC, yes/no | 109/196 | 28/23 | 0.0124 |
| Total bilirubin (mg/dL) | 0.8 (0.3, 5.1) | 0.9 (0.2, 3.8) | 0.9470 |
| Serum albumin (g/dL) | 4.3 (2.0, 5.1) | 4.1 (2.4, 5.2) | 0.0011 |
| Prothrombin time (%) | 91.4 (11.9, 122.9) | 88.9 (33.4, 122.5) | 0.1818 |
| Platelet count (×104/mm3) | 17.9 (1.4, 51.4) | 16.9 (2.8, 34.5) | 0.1531 |
| AST | 25 (12, 222) | 24 (10, 191) | 0.3413 |
| ALT | 20 (6, 206) | 17 (5, 232) | 0.6215 |
| M2BPGi | 1.2 (0.21, 11.93) | 2.18 (0.47, 10.82) | 0.0016 |
| eGFR (ml/min/1.73 m2) | 81 (5, 173) | 73 (7, 162) | 0.0709 |
| HbA1c (NGSP) | 5.7 (3.7, 12.6) | 5.7 (4.5, 9.8) | 0.5730 |
| Serum ammonia (μg/dL) | 38 (12, 195) | 40 (14, 206) | 0.7299 |
| BTR | 5.715 (1.93, 13.82) | 5.07 (1.69, 10.0) | 0.0289 |
| Serum zinc (μg/dL) | 74.2 (22.0, 124.6) | 69.5 (36.6, 118.2) | 0.1474 |
| ECW to TBW ratio | 0.389 (0.367, 0.425) | 0.398 (0.368, 0.421) | <0.0001 |
| SMI decline, yes/no/unknown | 94/209/2 | 27/24/0 | 0.0037 |
Continuous data are expressed as median (range). HCV, hepatitis C virus; HBV, hepatitis B virus; NBNC, non-B and non-C; LC, liver cirrhosis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; M2BPGi, Mac-2 binding protein glycosylation isomer; eGFR, estimated glomerular filtration rate; NGSP, National Glycohemoglobin Standardization Program; BTR, branched-chain amino acid to tyrosine ratio; ECW, extracellular water; TBW, total body water; SMI, skeletal muscle index.