Table 3.
Clinical asthma markers and inflammatory markers of subjects with asthma, classified by weight and O3I.
| Obese Asthma | Nonobese Asthma | |||||||
|---|---|---|---|---|---|---|---|---|
| Obese Asthma | >8% O3I | <8% O3I | >8% O3I | <8% O3I | p-Value * | Obesity × O3I Interaction | High vs. Low O3I | Obese vs. Nonobese |
| n | 37 | 98 | 20 | 87 | ||||
| ICS (μg beclomethasone eq/d) | 1000 (212.5–1000) (n = 36) |
1000 (1000–2000) (n = 61) |
1000 (500–1000) (n = 15) |
500 (500–1000) (n = 59) |
0.0002 | 0.1556 | 0.0104 | 0.0077 |
| ACQ6 | 0.33 (0–1.8) (n = 7) |
0.75 (0.3–1.5) (n = 86) |
0.5 (0.3–1.0) (n = 17) |
0.7 (0.2–1.3) (n = 84) |
0.6981 | 0.8864 | 0.4235 | 0.4948 |
| FEV1 (% predicted) | 82.49 ± 15.08 (n = 35) |
80.18 ± 19.37 (n = 84) |
72.37 ± 18.15 (n = 19) |
78.05 ± 19.48 (n = 85) |
0.0001 | 0.6616 | 0.4851 | 0.3445 |
| FVC (% predicted) | 94.04 ± 13.87 (n = 35) |
88.61 ± 15.84 (n = 84) |
87.42 ± 11.74 (n = 19) |
93.38 ± 17 (n = 85) |
<0.0001 | 0.2197 | 0.8011 | 0.3537 |
| FEV1/FVC (5) | 71.5 (63.9–77.7) (n = 35) |
74 (66.25–80) (n = 84) |
66 (55–71.6) (n = 19) |
68 (60–74) (n = 85) |
<0.0001 | 0.6012 | 0.1146 | 0.0035 |
| CRP (mg/mL) | 3.1 (1.25–8) (n = 33) |
5.59 (2.67–12.42) (n = 74) |
1.57 (0.9–7.28) (n = 11) |
1.77 (0.97–5) (n = 67) |
0.0003 | 0.0475 | ||
| IL-6 (pg/mL) | 0.30 (0.04–1.13) (n = 30) |
2.35 (1.61–3.37) (n = 53) |
1.77 (1.16–2.42) (n = 11) |
1.38 (0.9–2.11) (n = 65) |
0.0326 | 0.6909 | 0.1857 | 0.3207 |
| TNF (pg/mL) | 0.35 (0.18–0.9) (n = 27) |
1.41 (0.96–1.92) (n = 50) |
1 (0.46–1.54) (n = 10) |
1.23 (0.82–1.75) (n = 49) |
0.4769 | 0.3315 | 0.8142 | 0.2666 |
Data are presented as median (interquartile range) or mean ± standard deviation. Significant effects are highlighted in bold. ICS: inhaled corticosteroid; ACQ: Asthma Control Questionnaire; GINA: Global Initiative for Asthma; FEV1: Forced expiratory volume in 1 s; FVC: Forced vital capacity; CRP: C-reactive protein; IL-6: Interleukin-6; TNF-α: Tumour necrosis factor α. *: Two-factor ANOVA analysis performed, adjusted for age and gender, unless otherwise stated.