Table 2.
Summary of clinical observations used for evaluating the pathogenicity of recombinant viruses.
| Group | Mortality Rate (%) | Peak Viral Shedding (DPI) | Peak Viral Shedding (log10 copies/mL) | Onset of Diarrhea (DPI) † | Mean Average Daily Weight Gain ‡ |
|---|---|---|---|---|---|
| iPEDVPT-P5 | 87.5 (7/8) | 1 | 10.06 ± 1.14 | 1.00 ± 0.0 | −0.116 ± 0.135 |
| iPEDVPT-P5-96S | 80.0 (4/5) | 7 | 9.15 ± 0/91 | 3.83 ± 1.47 | −0.033 ± 0.062 |
| iPEDVPT-P96-5S | 83.4 (5/6) | 1 | 8.20 ± 1.70 | 1.00 ± 0.0 | −0.035 ± 0.049 |
| iPEDVPT-P96 | 40.0 (2/5) | 10 | 9.74 ± 0.74 | 2.38 ± 1.51 | −0.016 ± 0.055 |
| Mock | 0.0 (4/4) | ND | ND | ND | 0.051 ± 0.016 |
† Onset of diarrhea was defined as day post-inoculation when loose stools scored as two or above were recorded. ‡ Average daily weight gain (AVG) was calculated by dividing weight gained by survival days; mean value was calculated as dividing the sum of AVG by the number of piglets in the indicated groups that were not humanely euthanized.